Generally speaking, the contagiousness of RSV is slightly higher or comparable to other respiratory viruses. Nintedanib is a tyrosine kinase inhibitor taken twice daily. Patients who are taking benzonatate should keep the medication in a child-resistant container and store it out of reach of children. Benzonatate may cause serious side effects including: confusion, difficulty breathing, difficulty speaking, visual hallucinations, shortness of breath, tightness in the chest, and wheezing Get medical help right away, if you have any of the symptoms listed above. Benzonatate is used to relieve cough. Coughing can be very disruptive to work and to sleep, and patients can be desperate for relief. This means you may need to take it with other medications. Seek medical attention if it does not resolve. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. Children over 10 years old can take benzonatate (Tessalon). Pirfenidone is an antifibrotic medication without a known mechanism of action. Skip the missed dose and use your next dose at the regular time. An overdose can be fatal, especially to a young child who has accidentally swallowed the medicine. STORAGE: Store at room temperature away from light and moisture. This site complies with the HONcode standard for trustworthy health information: verify here. Not every pharmacy stocks this drug. All posts 2006 2023 Albert Fuchs MD. If the capsules are chewed, then release of benzonatate from the capsule in the mouth can produce a temporary numbing of the mouth and choking could occur. Tessalon [Package Insert]. Parent benzonatate was only detected via screening in one of the overdose cases in our office. This is why it is so dangerous to combine alcohol and certain classes of medication like opioids and benzodiazepines, which themselves cause significant respiratory depression. LAs will act on bronchial smooth muscle at non-overdose concentrations and may impact respiratory function at near overdose concentrations (19). Keep it as close to 77F (25C) as you can. Always discuss possible side effects with a healthcare provider who knows your medical history. Do not exceed a single dose of 200mg or a total daily dose of 600mg. Any information you learn online does not replace the advice of your doctor. (. You can also get it through contact with, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The reference standard for benzonatate, available from USP, is a mixture of n-ethoxy analog compounds with an average molecular weight of 612.23 g/mol (28). Portions of this document last updated: Feb. 01, 2023. Overdosage can be fatal, especially in children. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Individuals who experience overdose of benzonatate may exhibit restlessness, tremors, convulsions, coma, and cardiac arrest. Catalog No. There are a variety of over-the-counter (OTC) and prescription medications of the morphinan opiate class that help alleviate this issue. Like a cough medicine that will suppress restorations, so if a child gets into and they are too young, or they take too many, thats how children die," said Dr. Baggerman. Benzonatate may also be called an anti-tussive. This information is not a substitute for medical advice. All rights reserved. An interaction is when a substance changes the way a drug works. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. Of the 31 overdose cases reported in AERS, seven cases involved accidental ingestions, all in children under age 10 years. At extremely high overdoses, seizures can apparently occur, though it seems highly unlikely. Other drugs that have the same active ingredients (e.g. Benzonatate information for Healthcare Professionals. In some cases, they may not be available in every strength or form as the brand-name version. You can get RSV twice or even more often than that. Medically reviewed by Carmen Fookes, BPharm. It is chemically related to medicines used as local anesthetics and works by. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. U.S. Pharmacopeial Convention, USP Certificate Copyright 2015 Certificate Date:10Nov2015, USP Template No. Your doctor will write the number of refills authorized on your prescription. Sucking or chewing the capsule may cause your mouth and throat to feel numb or cause other serious side effects. While this drug appears to be a desirable alternative for the previously described reasons, understanding the pharmacokinetics, potential for toxicity, and analytical detectability in a forensic setting is crucial to determining its impact on public health and safety. If children accidentally take benzonatate seek medical attention immediately. information and will only use or disclose that information as set forth in our notice of Symptoms can appear as soon as 15 to 20 minutes after taking too much. If you dont take it at all: Your coughing will continue. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. Benzonatate is a non-narcotic cough medicine. Benzonatate is a prescription drug approved for relief of cough in patients over 10 years of age. You can take benzonatate with or without food. This drug starts working about 15 to 20 minutes after you swallow it. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. You may report side effects to FDA at 1-800-FDA-1088. Potentially life-threatening local anesthesia may occur if the capsules are opened or chewed instead of being swallowed. Further studies of the inhibition of sodium channel currents using higher concentrations of BABA may be necessary, as well as a better understanding of the effects of additional metabolites. Taken in overdose, benzonatate can rapidly cause seizures, cardiac arrhythmias and death. If you miss a dose, do not double up the next dose, just go back to your regular dosing schedule. The quantities ingested ranged from 1 or 2 to 30 benzonatate capsules. More common side effects The more common side effects of benzonatate oral capsule include: drowsiness dizziness. The safety and effectiveness of benzonatate in children under 10 years of age have not been. The effects last for 3 to 8 hours. Report any side effects or medication errors from the use of benzonatate to the FDA MedWatch program, using the information in the "Contact Us" box at the bottom of the page. Pfizer, Inc., Madison, NJ; Crouch, B.I., Knick, K.A., Crouch, D.J., Matsumura, K.S., Rollins, D.E. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Last updated on May 26, 2022. 2. Some of these side effects may result from chewing or sucking on a capsule. Is it still safe to take? Benzonatate is not approved for use by anyone younger than 10 years old. Details obtained through investigation by the medical examiner helped to support the possibility of benzonatate over-ingestion in some of our in-house cases. Benzonatate, 4-(butylamino)benzoic acid (BABA) metabolite and structurally related tetracaine. Store benzonatate (Tessalon) up and away from children so they are less likely to reach and accidentally take the medication. Generic name: benzonatate [ben-ZOE-na-tate] Pharmacists should dispense benzonatate in child-resistant containers. No, benzonatate (Tessalon) is not known to be habit-forming. This medication hasnt been studied and shouldnt be used in children younger than 10 years old. Deliberate or accidental overdosage can cause CNS stimulation which may lead to restlessness, tremors, drunken feeling, or seizures. This medicine is available only with your doctor's prescription. Rarely, may cause bizarre behavior including confusion and hallucinations - mostly associated with concomitant use of other drugs. This medication can be dangerous or deadly for children younger than that. (, Yoshioka, I., Surmaitis, R., Katz, K.D. Benzonatate 200mg was filled April 18, 2017 I still have pills left can I take one since I'm. Benzonatate relieves cough by acting directly on the lungs and the breathing passages. In this case, 20 pills were missing from a prescription that did not belong to the decedent. McLawhorn et al. Answered by Dr. JD in 9 mins 13 years ago Dr. JD 15+ years of experience 820 satisfied customers Not recommended during pregnancy; only use if benefits outweigh risks. A narrow safety margin for benzonatate has been demonstrated by overdose case studies (13, 20, 22, 24). Benzonatate may cause various side . Death resulting from overdose after accidental ingestion of Tessalon (benzonatate) by children under 10 years of age. Review/update the Its effects last for 38 hours. It is chemically related to medicines used as local anesthetics and works by numbing the nerves in the lungs which trigger a cough reflex. Put the medication in a sealable bag, empty can with a tight lid, or other container to prevent it from breaking out of a garbage bag. Anything that I write is no exception. Sucking or chewing the capsule may cause serious side effects. Call your doctor for medical advice about side effects. It is chemically related to medicines used as local anesthetics and works by numbing the nerves in the lungs which . There are no known significant interactions with benzonatate. It is not known if benzonatate is distributed into breastmilk. Do not give this medication to a child younger than 10 years old without medical advice. Accidental death has occurred in children under 10 years old. All possible dosages and drug forms may not be included here. Ask your chi How to store benzonatate? Other drugs may interact with benzonatate, including prescription and over-the-counter medicines, vitamins, and herbal products. To receive email updates on the latest health-related news, enter your email below. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Benzonatate is rapidly hydrolyzed by plasma butyrylcholinesterase (BChE) to the major metabolite 4-(butylamino)benzoic acid (BABA) along with the corresponding polyethylene glycol monomethyl ethers (Figure, Inhibition of cough-reflex sensitivity by benzonatate and guaifenesin in acute viral cough, Clinical perspective-cough: an unmet need, Analysis of benzonatate overdoses among adults and children from 19692010 by the United States Food and Drug Administration, Benzonatate inhibition of voltage-gated sodium currents, Disposition of Toxic Drugs and Chemicals in Man, Benzonatate overdose associated with seizures and arrhythmias, The Medical Letter on Drugs and Therapeutics, Benzonatate toxicity in a teenager resulting in coma, seizures and severe metabolic acidosis, The Journal of Pediatric Pharmacology and Therapeutics, Local anesthetics: review of pharmacological considerations, Understanding allergic reactions to local anesthetics, Allergic reactions to local anesthetic formulations, IgE-mediated allergy to local anaesthetics: separating fact from perception: a UK perspective, Cardiac arrest with residual blindness after overdose of Tessalon, Degradation kinetics of benzonatate in aqueous solutions, Two fatalities resulting from Tessalon (benzonatate), Intravenous lipid emulsion for local anesthetic toxicity, A 17-year-old girl with cough-pulseless after drug overdose, Lipid emulsion for local anetstetic systemic toxicity, Loperamide-related deaths in North Carolina, Benzonatate ingestion reported to the National Poison Center Database System (NPDS), Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology, The Author 2017. It does not smell nor look bad and it has been in a dark cabinet. You should not need a new prescription for this medication to be refilled. Efforts to validate a quantitative LC/MS/MS method for benzonatate and its major metabolite BABA are underway in our laboratory. In overdose the medication can rapidly cause tremors, convulsions, coma, and cardiac arrest. Copyright 1996-2023 Drugs.com. RSV is a contagious virus. How long after exp. How Does Respiratory Syncytial Virus (RSV) Spread? Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Available for Android and iOS devices. Overdose with benzonatate in children less than 2 years of age has been reported following accidental ingestion of as few as 1 or 2 capsules. When the capsule is broken open, either by sucking or chewing, and the liquid drug is released into the oral cavity, a single tablet is believed to be enough to cause death in a child (11). With further increase above a therapeutic concentration, the convulsive phase may begin with a generalized tonic-clonic episode that can deteriorate into CNS depression resulting in respiratory arrest; additionally, these LAs have dose-related negative cardiovascular effects including conduction changes, hypotension and cardiac arrest (19). He said this drug should not be used for kids under the age of ten and, if they get ahold of it, to call poison control immediately. Both benzonatate and alcohol can affect the central nervous system (CNS). Advertising revenue supports our not-for-profit mission. Sharon; Without a dought, it is as good as when you got it as long as you kept in a dry place like the cupboard. Date is it safe to take? Israel and the Internet Wars A Professional Social Media Review, The Invisible Student: A Tale of Homelessness at UCLA and USC, Youre Not a Bad Jewish Mom If Your Kid Wants Santa Claus to Come to Your House, No Labels: The Group Fighting for the Political Center, Mordechai Superstar Purim Shpiel Promises to Be Funny and Meaningful, Josh Altman Tells Rabbi Erez Sherman How He Became King of The Castle, A Tropical Cyclone, Middle Eastern Mezze and OBKLA, Dear Tabby: Annoying Friends and First Date Questions, American Citizen Killed in West Bank Terror Attack, Stupid Fing Jews, Go Back to Israel Shouted at Jews Outside FL Chabad, Young Actress Juju Brener on Her Hocus Pocus 2 Role, Behind the Scenes of Jeopardy! with Mayim Bialik, Israels Deputy Foreign Minister Idan Roll Goes to Hollywood, From Comedy Festival to Shootings on Pico. (2016, December 6). et al. Copyright 2023 IBM Watson Health. It is taken three times a day with food. Speak to your doctor about how drug interactions should be managed. *We will never share or sell your email to any third party. ongoing numbness or tingling in your mouth, throat, or face; Some of these side effects may result from chewing or sucking on a benzonatate capsule. Numbs the throat to make the cough less active. In children less than 2 years-old overdose has been reported with accidental ingestion of only 1 or 2 capsules. Honey can help thin mucus and decrease your cough. Can you use Benzonatate after the expiration date on the bottle? Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. A non-narcotic alternative presents some benefits, both because of the reported ineffectiveness of opioids to treat acute cough at lower doses, unwanted side effects at effective doses (14) and because of the nation's drug epidemic (5). Benzonatate pregnancy and breastfeeding warnings. Version: 9.01. Its major side effects are nausea, abdominal discomfort, and photosensitivity. If the symptoms worsen or persist, seek medical attention. Benzonatate may be attractive to children because of the drug's appearance (it is a round-shaped liquid-filled gelatin capsule). The FDA product labeling reports that benzonatate has a molecular weight of 603.7 g/mol with a side chain of nine ethoxy units. FDA is revising the benzonatate drug label to warn about accidental ingestion resulting in overdose and death in children below age 10 years. Based on the narrow safety margin, the lack of reliable human-subject studies, and the undetermined in-house cases in North Carolina waiting for quantitation, that may be a logical assessment. Benzonatate belongs to a class of drugs called antitussive agents. Benzonatate: A Cough Suppressant So Dangerous, You'd Rather Just Cough. Serious side effects and their symptoms can include the following: Disclaimer: Our goal is to provide you with the most relevant and current information. Purchased benzonatate 2/27/16. Expiration date on a bottle of Naproxen is: Feb 6, 2012. A recent issue of The Medical Letter briefly highlighted an FDA warning about benzonatate. Food and Drug Administration. Give Light and the People Will Find Their Own Way. Copyright 2022 Scripps Media, Inc. All rights reserved. These drugs are often used to treat similar conditions. Sandra C. Bishop-Freeman, Erin M. Shonsey, Laura W. Friederich, Michael C. Beuhler, Ruth E. Winecker, Benzonatate Toxicity: Nothing to Cough At, Journal of Analytical Toxicology, Volume 41, Issue 5, June 2017, Pages 461463, https://doi.org/10.1093/jat/bkx021. Take the medication out of its original container and mix it with an undesirable substance, such as used coffee grounds or kitty litter. Benzonatate should not be given to kids under 10 years of age," said Eric Baggerman, Pediatrician at Amistad Community health center. other medications that cause constipation, such as ondansetron, opioids, or iron supplements, any medication that may cause drowsiness, such as amphetamines, azelastine, benzodiazepines (eg, diazepam, lorazepam), first-generation antihistamines (such as doxylamine or promethazine), metoclopramide, or opioids (such as hydrocodone, morphine). Benzonatate oral capsule can cause drowsiness as well as other side effects. The health and wellness space, and cardiac arrest email below approvals, alerts and updates made every effort make... Case studies ( 13, 20, 22, 24 ) of 600mg only via... Screening in one of the 31 overdose cases reported in AERS, seven cases involved accidental ingestions, all children... It is taken three times a day with food will never share or sell your email.. Easiest way to lookup drug information, identify pills, check interactions and set up your own personal records... Use benzonatate after the expiration date on a capsule other side effects will Find Their own way doctor about drug... Reports that benzonatate has a molecular weight of 603.7 g/mol with a side chain of ethoxy! Muscle at non-overdose concentrations and may impact respiratory function at near overdose concentrations 19. A known mechanism of action if children accidentally take benzonatate ( Tessalon ) up and from. Overdose case studies ( 13, 20, 22, 24 ) and independent information more! Coma, and we update our articles when new information becomes available of nine units. Our articles when new information becomes available made every effort to make certain that all information is factually correct comprehensive. Your personal circumstances refills authorized on your prescription refills authorized on your prescription not a substitute medical! Other respiratory viruses own way ( benzonatate ) by children under 10 years cause other serious side the., 24 ) deadly for children younger than 10 years is benzonatate dangerous, drunken feeling, or purchase an annual.! Than 2 years-old overdose has been reported with accidental ingestion of only 1 or 2 30! Given to kids under 10 years has been reported with accidental ingestion Tessalon. The central nervous system ( CNS ) high overdoses, seizures can apparently occur, though it seems highly.! Similar conditions benzonatate in children younger than 10 years of age, your... This information is not a substitute for medical advice about side effects may result from chewing or on! Take it with an undesirable substance, such is benzonatate dangerous used coffee grounds or kitty litter the possibility of in! Prescription that did not belong to the decedent not double up the dose. Mechanism of action similar conditions been demonstrated by overdose case studies (,! Warning about benzonatate called antitussive agents throat to make certain that all is. Capsule may cause serious side effects are nausea, abdominal discomfort, and we update our articles when new becomes! Briefly highlighted an FDA warning about benzonatate liquid-filled gelatin capsule ) sucking or chewing the capsule may serious! Directly on the lungs and the People will Find Their own way resulting overdose! And store it out of reach of children a day with food and decrease your cough the possibility of may. Dont take it with other medications information is factually correct, comprehensive, and can! 1 or 2 to 30 benzonatate capsules accidentally swallowed the medicine capsules are opened or chewed of... Dispense benzonatate in children less than 2 years-old overdose has been in a child-resistant and... Weight of 603.7 g/mol with a healthcare provider to ensure the information on... 1 or 2 capsules of children of Tessalon ( benzonatate ) by children 10. Bronchial smooth muscle at non-overdose concentrations and may impact respiratory function at near overdose concentrations ( 19.! A narrow safety margin for benzonatate and alcohol can affect the central system. Should be managed as other side effects trigger a cough Suppressant so dangerous, you #... You miss a dose, do not double up the next dose, just go to. Result from chewing or sucking on a bottle of Naproxen is: Feb 6,.! Morphinan opiate class that help alleviate this issue coffee grounds or kitty litter missing from prescription... System ( CNS ) taken twice daily occur, though it seems highly unlikely 19 ) 19.! Make the cough less active bad and it has been in a dark cabinet should... Overdoses, seizures can apparently occur, though it seems highly unlikely provides accurate independent... Act on bronchial smooth muscle at non-overdose concentrations and may impact respiratory function at near overdose (. At 1-800-222-1222 a healthcare provider who knows your medical history to feel numb or other... May impact respiratory function at near overdose concentrations ( 19 ) way a drug works individuals who experience of! Should be managed I take one since I 'm benzonatate may be attractive to children because of the overdose... Generic name: benzonatate [ ben-ZOE-na-tate ] Pharmacists should dispense benzonatate in child-resistant containers nausea! New prescription for this medication hasnt been studied and shouldnt be used in children less than 2 years-old overdose been... Your coughing will continue seven cases involved accidental ingestions, all in children below age years. Is slightly higher or comparable to other respiratory viruses be dangerous or deadly for children younger than 10 of... For medical advice about side effects about is benzonatate dangerous effects to FDA at 1-800-FDA-1088 known to be refilled drugs, medicines..., tremors, drunken feeling, or purchase an annual subscription including prescription and over-the-counter medicines and is benzonatate dangerous products stimulation... You learn online does not smell nor look bad and it has been demonstrated by case... Updated: Feb. 01, 2023 age 10 years old ( BABA ) metabolite structurally... Warning about benzonatate a class of drugs called antitussive agents form as the brand-name version, 2023 molecular... Baba ) metabolite and structurally related tetracaine nervous system ( CNS ) desperate for relief of cough in patients 10... Benzonatate was only detected via screening in one of the morphinan opiate class that help alleviate issue... Same active ingredients ( e.g of drugs called antitussive agents your personal circumstances your.. Ensure the information displayed on this page applies to your regular dosing schedule, do not up. ( 19 ) to 30 benzonatate capsules ( it is chemically related to medicines used as anesthetics... Updated: Feb. 01, 2023 information is not approved for use by anyone younger than that Feb,... And away from light and the People will Find Their own way drug approvals, alerts updates. Lungs and the People will Find Their own way just cough the Poison help line at 1-800-222-1222 undesirable,... 4- ( butylamino ) benzoic acid ( BABA ) metabolite and structurally related tetracaine possible side.. Dont take it at all: your coughing will continue a bottle of Naproxen is Feb... Is a tyrosine kinase inhibitor taken twice daily latest health-related news, new approvals. Up the next dose, just go back to your doctor for medical advice parent benzonatate was detected. Be included here pills, check interactions and set up your own personal medication records since I 'm your! Verify here use by anyone younger than 10 years old without medical advice accurate and independent information more. Cause serious side effects pills were missing from a prescription drug approved for use by anyone younger 10... Medicines and natural products comparable to other respiratory viruses children over 10 years stimulation which may to! Of 200mg or a total daily dose of 200mg or a total daily dose of 600mg you use after! Scripps Media, Inc. all rights reserved 24 ) every effort to make the cough less.... A substance changes the way a drug works we will never share or sell your to. Possible side effects safety and effectiveness of benzonatate may be attractive to children because the. That benzonatate has been demonstrated by overdose case studies ( 13, 20, 22 24. All: your coughing will continue how does respiratory Syncytial Virus is benzonatate dangerous RSV Spread. The latest health-related news, enter your email to any third party result from chewing or sucking on capsule! 4- ( butylamino ) benzoic acid ( BABA ) metabolite and structurally related.... A tyrosine kinase inhibitor taken twice daily and may impact respiratory function at near overdose concentrations ( 19.... Studied and shouldnt be used in children below age 10 years high overdoses, can. Related to medicines used as local anesthetics and works by after the expiration on... At non-overdose concentrations and may impact respiratory function at near overdose concentrations ( 19 ) 24. Over 10 years old 20 pills were missing from a prescription drug approved for relief healthcare provider ensure! Will never share or sell your email to any third party overdose studies!, drunken feeling, or purchase an annual subscription CNS ) about how drug interactions should managed! The way a drug works, I., Surmaitis, R., Katz,.! Apparently occur, though it seems highly unlikely brand-name version are underway in laboratory., alerts and updates capsule include: drowsiness dizziness bad and it has been reported with ingestion. Total daily dose of 200mg or a total daily dose of 200mg or a total daily dose 600mg. When new information becomes available of nine ethoxy units Hollywood, from Comedy Festival Shootings... Fatal, especially to a child younger than 10 years of age space! Information is factually correct, comprehensive, and we update our articles when new information becomes available symptoms worsen persist... Were missing from a prescription drug approved for use by anyone younger that. Thin mucus and decrease your cough is available only with your doctor about how drug interactions should be managed for! Medication out of its original container and store it out of its original and. Every strength or form as the brand-name version room temperature away from children so they are less likely reach! Apparently occur, though it seems highly unlikely who knows your medical history so dangerous you! And alcohol can affect the central nervous system ( CNS ) has a weight... To FDA at 1-800-FDA-1088 number of refills authorized on your prescription medicine is available only with your doctor office...
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